The national acute spinal cord injury nascis is com posed of three multicentric. Bolus dose of 30 mgkg of body weight over 15 minutes, followed by a 45minute pause, and then a 23hour continuous infusion of 5. National acute spinal cord injury study iii michael bracken. Methylprednisolone a haute dose dans le traitement des. The clinical recommendation of steroid therapy is based generally on the national acute spinal cord injury study nascis ii and iii 276, 286, 289. Nascis iii randomized 499 patients within six hours of injury.
In nascis iii it is also likely that all possible comparisons between 0 and 8 hours were made 1 hour and 18 hours, 2 hours and 28 hours, 3 hours and 3 8 hours, and so on. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of 41 columna. Methylprednisolone in the management of spinal cord. Corticoides dans les traumatismes du systeme nerveux. This randomized clinical trial rct continues the work of the national acute spinal cord injury study nascis group in attempting to treat patients with acute. Methylprednisolone in the management of spinal cord injuries ncbi. Nascis iii additionally reported that prolonged steroid use was. Nascis iii mp 3 hrs postraumaticas mp 3 8hrs postraumantismo mantenidos en tx con mp durante 24 horas. With certainty, only the most interesting data were reported. Nascis ii, 1990 was a multicenter, doubleblinded rct that randomized 487 patients with acute traumatic sci to three arms. In the nascis iii protocol, the dose mentioned in nascis 2 for 24 h if patient presents 3. Pdf highdose methylprednisolone for acute closed spinal cord. Atencion integral al paciente con lesion medular aguda.
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